Loading Events

« All Events

  • This event has passed.

Ultrafast structural dynamics studies of molecular and biomolecular systems

November 22 , 13:00 14:00

Speaker: Prof. Henrike M. Müller-Werkmeister
Affiliation: University of Potsdam, Germany
Click here to join the meeting

Observing molecular dynamics experimentally with highest spatial and temporal resolution combined, is one of the biggest challenges in chemistry and biochemistry. Understanding and resolving structure-dynamics relationships will help to further understand complex molecular function. Few experimental methods allow to resolve multiscale dynamics and structural information in the same experiment from femtoseconds onwards.
2D-IR spectroscopy (ultrafast multidimensional infrared spectroscopy), can be performed as table-top experiment in solution state and is the key methodology in the laser lab in Potsdam. Inhomogeneities of molecular ensembles are accessible and can be resolved by 2D-IR, similarly energy transport pathways become directly accessible on the relevant timescale. I will introduce the basics of 2D-IR and review progress on studies of biomolecular dynamics (proteins and carbohydrates [1]).
While 2D-IR is an extremely powerful method to investigate molecular dynamics in solution, it doesn’t provide full atomic resolution. Ultrafast time-resolved diffraction, either using X-Rays at XFELs and synchrotrons, now well established for protein dynamics [2,3] and under development as single-shot serial experiment for materials, and UED – ultrafast electron diffraction [4], primarily on materials, give access to fully resolved dynamic structures at room temperature

[1] J. Chem. Phys. 158, 145101, 2023
[2] Nat. Methods, Vol. 15, pp. 907-904(11), 2018
[3] Science 365 (6458), 1167-1170, 2019
[4] Nat. Comm., 11 (1), 2020

Skip to content