Rheological phenomena in biological systems and their importance in brain tumors development

Speaker: Prof. Katarzyna Pogoda
Affiliation:  Institute of Nuclear Physics, Polish Academy of Sciences, Krakow Poland

Kliknij tutaj, aby dołączyć do spotkania
Identyfikator spotkania: 319 721 816 497
Kod dostępu: cSaLPY
Pobierz aplikację Teams | Dołącz w Internecie

The brain is one of the softest tissues in the body that responds in the time-dependent manner when subject to different loading conditions. Under compression, tension or shear it behaves as non-linear, viscoelastic body, and the response to shear deformation is often different from response to uniaxial strain. Despite its natural softness, brain tissue compression-stiffens, and the cells within the brain tissue are exposed to forces and stiffnesses higher than those predicted from measurements in the low strain limit of tissue samples ex vivo. In this regard, it is important to understand how brain cells adopt to an increased stiffness of their surrounding and whether this implies changes in their fate and function. In parallel, brain is also highly viscous, and brain cells’ response to viscosity is  different from their response to elastic resistance. Recent development of soft viscoelastic materials where the elastic and viscous moduli can be independently tuned has opened up the possibility to characterize the impact of both elasticity and viscous dissipation on brain cells. The potential of mechanical stimuli to directly influence cell function is relevant to brain tumor growth and essential for understanding how cells and tissues develop under normal conditions and how they change when exposed to altered mechanical loads. Increased mechanical characterization of the brain and further investigation of the mechanobiology of single brain cells under active mechanical forces have both diagnostic and therapeutic relevance.

References

1. Pogoda K, Charrier EE, Janmey PA. A Novel Method to Make Polyacrylamide Gels with Mechanical Properties Resembling those of Biological Tissues. Bio Protoc. 2021;11(16):e4131. Epub 2021/09/21. doi: 10.21769/BioProtoc.4131. PubMed PMID: 34541049; PMCID: PMC8413537.
2. Charrier EE, Pogoda K, Li R, Wells RG, Janmey PA. Elasticity-dependent response of malignant cells to viscous dissipation. Biomech Model Mechanobiol. 2021;20(1):145-54. Epub 2020/08/14. doi: 10.1007/s10237-020-01374-9. PubMed PMID: 32785801; PMCID: PMC7892690.
3. Pogoda K, Janmey PA. Glial Tissue Mechanics and Mechanosensing by Glial Cells. Front Cell Neurosci. 2018;12:25. Epub 2018/03/09. doi: 10.3389/fncel.2018.00025. PubMed PMID: 29515372; PMCID: PMC5826335.
4. van Oosten ASG, Chen X, Chin L, Cruz K, Patteson AE, Pogoda K, Shenoy VB, Janmey PA. Emergence of tissue-like mechanics from fibrous networks confined by close-packed cells. Nature. 2019;573(7772):96-101. Epub 2019/08/30. doi: 10.1038/s41586-019-1516-5. PubMed PMID: 31462779.

Chairman: Prof. Jacek Gapiński

Google Calendar

iCal Export