Mechanisms of nucleic acid recognition in DNA repair

Speaker: Prof. Marcin Nowotny
Affiliation: International Institute of Molecular and Cell Biology, Medical University of Warsaw, Warsaw Poland

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Meeting ID: 365 747 902 735, Passcode: 6xhjAa
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DNA, which stores genetic information, is constantly subject to chemical damage. This distorts the blueprint of a living cell and can have catastrophic consequences. Life has evolved many DNA damage repair mechanisms that effectively recognize and remove lesions in genetic information. We are using structural biology to understand these mechanisms at the level of the individual protein atoms involved. In this talk, I will describe how a very general repair pathway, called nucleotide excision repair, localizes DNA damage in bacteria. I will also talk about the processing of branched DNA structures, which are intermediates of another general pathway called homologous recombination. Using these examples, I will also discuss some new general principles of nucleic acid recognition by proteins. I will also give a brief overview of recent developments in structural biology, particularly the development of cryo-electron microscopy. 

Chairman: Prof. Jacek Gapiński

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